alzheimers news-a new alzheimers nasal spray

ALZHEIMERS NEWS-A NEW ALZHEIMERS NASAL SPRAY

recently i mentioned this new alzheimers nasal spray in a blog
it intrigues me
that you could spray something in you nose that may remove amyloid plaque in the brain
thus
slowing down alzheimers

slowing down or stopping alzheimers ill take either one 

i figure if i can slow mine down some ill die from something else 
maybe 
like a sudden heart attack while working in my garden would be my choice
sparing me and my family that long road down the alzheimers final slide down that slope that happens in late alzheimers

yep ill take slowing it down anytime

just think if a nasal spray worked there would be no monthly or bimonthly infusions at an infusion center
you could just spray it up your nose after brushing your teeth

sounds too good doesnt it
no
it may happen

being patient did a good article on this new nasal spray

the nasal spray contains proteins that which when sprayed in the nose causes the bodys immune system located in the lymph nodes of the head and neck to induce macrophage and microglia the brains garbage truck guys to enter the brain and remove amyloid plaques that have accumulated
the hope is that removing these amyliod plaques may slow down alzheimers

the company that makes this alzheimers nasal spray called protollin is about to start a phase 1 study 
this will be on a limited number of folks using different doses and schedules to see which works the best and to see if there are significant side effects

these 16 study subjects have early alzheimers and are between 60-85 and have amyloid plaque buildup based on amyloid pet scans
they will be treated for 6 months

if this turns out ok then a phase 2 study would be done on a larger number of folks to see if the doses chosen work and if there are any side effects that show up 

occasionally if the phase one study looks real real promising then the fda will let them jump the phase 2 study and go right to the phase 3 study
thats what biogen was able to do with aduhelm or aducanumab

sometimes though its not good to take short cuts
as the problems with aduhelm or aducanumab are demonstrating

sometimes you cant rush science

if this turns out ok then a phase 3 study would be done on an even larger number of folks
this final study will really tell them if it works and if any new side effects show up in the larger group of folks

the time from the start of phase one to the end of phase 3 to final approval for use will be around 10 years
this company predicts 5 years

i am 72 
if it works i would be 82
thats too late for me
unless
i could get in a clinical trial 
which i cant
since im in the aduhelm clinical trial

thats true of not just this protollin drug but any new alzheimers drug in phase 1 studies now
so 
this is why probably aduhelm is my last chance to get a drug that will slow down or help me 

this protollin study is not even listed in clinicaltrials.gov yet

the phase 2 study probably wont happen for 2+ years
the phase 3 study probably wont happen for 5+ years
the company is hoping for a shorter timeline

if you are in the alzheimers world this is how you identify studies that may help you or your loved ones 
this is how i found aduhelm or aducanumab 8 years ago

the clock is ticking

the organicgreen doctor