OTC MEDS CAUSE THIS
healthtap.com
in alzheimers disease as the brain and nerve cells get damaged
the substance in the nerve cell endings called acetylcholine
starts to decrease
this acetylcholine in needed for the nerve cells to fire
ie for them to work
as alzheimers disease destruction continues
these levels of acetylcholine get lower and lower
then enter
aricept (donepezil) that is used to treat alzheimers symptoms
it inhibits an enzyme called acetycholinesterase
which is the enzyme that breaks down the acetycholine
by inhibiting this enzyme
it makes more acetylcholine available for the nerve cells
to work better those that are left in the brain
this week a study was reported on some otc meds and rx meds
that may have an effect on this system
benadryl (diphenahydramine) that is used for allergies allergic reaction
and commonly sold as a sleep aid
doxepin (brand sinequan) is an antidepressant that is used some for
depression or chronic itching
oxybutynin (brand ditropan) is a bladder medicine that many will
recognized as having been advertised a lot on tv in the past
when these are taken at usual doses some low doses for at least 3 years
they increase the chances of getting alzheimers disease by 60+- %
that is a significant increase
one of the warnings on my aricept (donepezil) that i take
says not to take antihistamines with it
thats benadryl claritin zyrtec allegra and chlortrimeton
since it blocks acetylcholines effect
it counteracts the effects of the aricept
gosh durn
theres enough side effects from the aricept
if i take it i want it to do its job
of raising the acetycholine in the brain
now these studies were done on older folks over 65
for a seven year period
not sure what effect it would have on a younger population
say like kids and young adults
even with this new evidence these drugs cause drowsiness
and can cause confusion in older folks
they are some of the meds that are looked at when someone
complains of memory loss
they are usually recommended to be discontinued
note the doxepin shouldnt be discontinued if its being
used for depression unless under the direction of a
medical provider
i can just hear the doctors as they prescribe ditropan for
bladder control
now your bladder will start working better
but
your brain wont be
wonder what happens if you add on risk factors like
high blood pressure high cholesterol diabetes family history
of alzheimers genetic predisposition to alzheimers
it is concerning since so many folks take this stuff
so
its seems the recommendation will be
dont take these things especially as you get older
there are other substitutes
like
use other sleep aids
use other newer antihistamines like loratidine
unless of course you take aricept (donepezil)
use other antidepressants like citalapram sertraline fluoxetine
ie celexa zoloft prozac
use another approach or med for you bladder control
it seems throughout medicine
that there are always these things that drugs cause
that show up years and years later
this one seems disconcerting to me
60% is a large number
and
like cancer
no one wants to get alzheimers disease
even me
the organicgreen doctor
And those of us with allergies take lots of those bad boys...time to reevaluate.
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